Anti-Inflammatory Supplements for Joints: Top 10 Picks for Pain Relief and Mobility

If your knees creak when you get out of bed, or your hips feel stiff after a long drive, those little reminders are often signs of how much your joints have carried you through the years. 

But ongoing joint pain, stiffness, and reduced mobility can make it harder to stay active, maintain independence, and enjoy everyday life. 

With millions of adults over 50 reporting joint discomfort, supporting joint health has become more important than ever, especially for people managing chronic diseases like osteoarthritis, rheumatoid arthritis, inflammatory bowel disease, or long-term joint inflammation.

While regular movement, a balanced diet, and a healthy weight all play major roles in reducing pain, many people turn to anti-inflammatory supplements for joints as an added layer of support. 

In this guide, you’ll find the top 10 anti-inflammatory supplements for joint pain, backed by real studies and expert insights. We’ll cover what each supplement does, the research behind it, and how to choose the right option for your needs. 

1. Turmeric/curcumin 

Turmeric is one of the most widely researched natural remedies for osteoarthritis pain and joint inflammation, and for good reason. Its active compound, curcumin, delivers powerful anti-inflammatory properties that help reduce inflammatory cytokines, support mobility, and ease joint stiffness. 

For many people, curcumin is one of the best supplements for joint mobility because it targets inflammation at the source, making it especially helpful for conditions like knee osteoarthritis, rheumatoid arthritis, and chronic joint pain.

A major 2021 review published in BMJ Open Sport & Exercise Medicine found that turmeric/curcumin provided significant improvement in pain relief and physical function for people with knee osteoarthritis. Additional research shows curcumin may help reduce inflammatory markers in rheumatoid arthritis. 

Turmeric contains only a small amount of curcumin, so experts recommend taking it as a supplement. However, Curcumin is notoriously hard for the body to absorb; hence, pairing it with healthy fats or piperine (black pepper extract) can dramatically increase bioavailability.

For a clean, organic option formulated for maximum absorption, Why Not Natural’s Organic Turmeric & Curcumin Capsules with Ginger and Black Pepper offer a targeted blend that supports joint pain relief, mobility, and long-term joint health. 

The added ginger provides complementary anti-inflammatory benefits, while black pepper enhances absorption so your body can use more of the curcumin you take.

While curcumin is generally safe, people taking blood thinners, chemotherapy drugs, or certain prescription medications should always consult their doctor first. 

2. Glucosamine and chondroitin 

Glucosamine and chondroitin are two of the most widely researched joint-supporting nutrients, and for good reason. Both are naturally found in cartilage, the protective tissue that cushions your joints and absorbs impact with every step, bend, or twist.

In a 2024 meta-analysis of 25 randomized controlled trials, scientists found that these supplements offer meaningful benefits for people with knee osteoarthritis:

• Chondroitin Sulfate was associated with reduced pain and improved physical function.

• Glucosamine significantly slowed joint-space narrowing, an early sign of cartilage loss, suggesting it may help preserve the integrity of your joints over time.

While the combination didn’t consistently outperform either nutrient on its own, researchers believe this may be due to limited high-quality trials studying them together, not that the combo is ineffective.

So how do Glucosamine and chondroitin work?

Glucosamine supports the production of glycosaminoglycans, which act as the “building blocks” of healthy cartilage. It’s especially valued for its ability to reduce stiffness and support mobility. 

Chondroitin on its own helps protect cartilage from breakdown, attracts water into connective tissue (which supports cushioning), and may calm low-grade inflammation that contributes to discomfort.

Together, they create a powerful foundation for joint comfort, especially for people managing osteoarthritis, long-term joint wear, or age-related stiffness.

At  Why Not Natural, we offer a blend that delivers both nutrients in clinically relevant doses. Our Glucosamine + Chondroitin + MSM Joint Support provides comprehensive support for comfort, flexibility, and healthy aging joints, all in one simple daily formula.

3. Collagen

Collagen is a key protein that helps hold your cells and tissues together.

As we age, the body’s natural collagen production declines. This reduction can contribute to joint stiffness, discomfort, and a higher risk of cartilage wear. 

While collagen is often associated with skin and muscle health, research shows it can also support joint function and reduce arthritis symptoms.

A meta-analysis of 41 studies in 2020 found improvements in pain and cartilage function. 

Types I and III collagen, found in skin, bones, tendons, and muscles, strengthen the tissues surrounding the joints, enhancing overall joint stability and resilience. 

While more research is needed, collagen supplements can be a valuable part of a plan for people managing osteoarthritis, joint stiffness, or age-related discomfort.

Need an easy daily option? Why Not Natural’s Liquid Collagen Drops combine hydrolyzed marine peptides and biotin for maximum absorption. 

You may also like: What is collagen good for?

4. Ginger

Ginger is a natural anti-inflammatory that has been shown to help reduce joint pain and stiffness. 

While studies on ginger specifically for menopause-related joint pain are limited, evidence suggests that it can be especially beneficial for adults in midlife managing age-related joint stiffness. 

5. SAM-e 

S-adenosyl-methionine, better known as SAM-e, is a naturally occurring compound in the body that offers anti-inflammatory and cartilage-supporting effects. 

Studies suggest that SAM-e can help ease osteoarthritis pain, performing similarly to NSAIDs like ibuprofen or celecoxib, but without the gastrointestinal or kidney-related side effects often associated with long-term medication use.

While research is still limited and sometimes mixed, many integrative medicine experts recognize SAM-e as a useful option for long-term joint support, especially when paired with other joint-friendly supplements like MSM.

6. Vitamin D

Studies indicate that individuals with rheumatoid arthritis frequently have reduced vitamin D levels, which could play a role in ongoing joint pain and inflammation.

While taking a vitamin D supplement isn’t a cure, it can support your body’s natural ability to maintain joint and bone health, potentially enhancing the effectiveness of other arthritis treatments.

For those looking for a high-quality, convenient supplement, these Organic Vitamin D3 with K2 capsules combine vitamin D3 with vitamin K2 to help direct calcium to your bones and joints, supporting strength, mobility, and overall skeletal health. 

Related reading: Taking Vitamin D? Here’s Why You Need K2 Too.

7. Vitamin E

Emerging research suggests that vitamin E may also play a role in joint health. Studies indicate it could help slow the progression of osteoarthritis and support the growth of new cartilage cells. 

While more conclusive research is needed, vitamin E remains a valuable addition to a joint-support routine.

Beyond joints, vitamin E offers a range of health benefits, including supporting vision, brain function, and skin health. 

It’s important to note that high doses of vitamin E can interact with blood-thinning medications, so consulting your doctor before adding a supplement is recommended.

8. Fish oil (omega-3 fatty acids)

Fish oil provides high amounts of omega-3s—especially EPA and DHA—which are known for their strong anti-inflammatory properties that may aid in maintaining healthy joints.

These fats are especially beneficial for people with rheumatoid arthritis, as studies show they can reduce joint pain, stiffness, and swelling. 

By calming inflammation, omega-3s may even help some individuals reduce their reliance on pain medication and avoid the side effects associated with NSAIDs.

While salmon, mackerel, and sardines naturally supply omega-3 fatty acids, many individuals prefer using supplements to ensure they get enough each day.

Aim for at least 1 gram each of EPA and DHA per serving. Vegetarians can opt for algae-based omega-3 supplements.

9. Boswellia serrata extracts

Boswellia serrata, also known as Indian frankincense, is an herbal extract long used in Ayurvedic medicine for its anti-inflammatory and joint-supporting properties. 

Its active compounds, Boswellic acids, have been shown to help reduce inflammation, ease joint pain, and may even protect cartilage from breakdown.

A 2025 review and meta-analysis of knee osteoarthritis supplements found that Boswellia-based products, particularly formulations like Aflapin, which combines Boswellia with other plant compounds, were among the most effective for reducing pain and improving joint mobility. 

When shopping, look for labels that include “5-Loxin” or “AKBA,” which indicate higher concentrations of the active compounds. Typical daily doses range from 100 to 250 mg.

Although Boswellia is typically safe for managing joint discomfort, it may interact with medications such as blood thinners, NSAIDs like ibuprofen, antidepressants, anti-anxiety drugs, and immunosuppressants. Consult your healthcare provider before using it.

10. MSM (Methylsulfonylmethane)

MSM (methylsulfonylmethane) is a natural sulfur compound present in plants, animals, and humans, and it helps support the health of connective tissues.

Its anti-inflammatory properties may help improve joint comfort, reduce swelling, and support overall mobility.

Research supports its benefits for joint health. In a 2023 randomized, double-blind study of 88 participants with mild knee discomfort, daily MSM supplementation for 12 weeks led to noticeable improvements in pain and overall well-being compared to a placebo. 

Another study found that a combination of MSM with glucosamine and chondroitin was more effective at supporting joint health than glucosamine and chondroitin alone. Typical daily dosages range from 2 to 3 grams, but it’s important to consult your doctor if you take blood thinners or have other health conditions.

For a convenient, lab-tested-for-purity-and-accuracy option, this Glucosamine + Chondroitin + MSM Joint Support combines these three compounds in clinically relevant doses, delivering comprehensive support for joint comfort, flexibility, and long-term mobility in one simple supplement.

Read also: Top 7 Supplements For Arthritis Relief, Approved Solutions.

Factors to consider before buying supplements for joints

Choosing the right supplement to reduce joint inflammation can feel overwhelming. Between bold claims, long ingredient lists, and endless options online, it’s easy to get confused about what actually matters.  

Below, we provide key factors to keep in mind when evaluating any joint product.

Verify product quality and transparency 

Because dietary supplements aren’t regulated like pharmaceuticals, the burden falls on consumers to look for signs of quality.

Third-party testing is one of the strongest indicators of a trustworthy product. Certifications from organizations such as USP, NSF International, or ConsumerLab.com verify that what’s listed on the label is actually in the bottle and that contaminants are not present.

These seals also confirm the product meets Good Manufacturing Practices (GMP), ensuring proper strength, purity, and consistency.

Another helpful sign is the presence of a lot number or batch number.

Brands that include this information demonstrate accountability and traceability, something you want in case of a recall or safety concern.

At Why Not Natural, we emphasize clean formulations, transparent labeling, and high manufacturing standards. All of our products are tested for accuracy and purity by Labdoor.

You can learn more about our standards here.

Watch out for unrealistic or illegal claims

If a supplement promises to cure arthritis, reverse cartilage damage, or eliminate pain instantly, that’s an immediate red flag. 

By law, dietary supplements cannot claim to diagnose, treat, cure, or prevent diseases. Furthermore, most supplements don't go through the same rigorous approval process from the Food and Drug Administration (FDA) as pharmaceuticals; hence, brands promising to cure arthritis, reverse cartilage damage, or eliminate pain instantly are ignoring FDA guidelines and should be avoided.

Stick with companies that use realistic, evidence-informed language. A good brand focuses on support, comfort, and mobility, not miracle fixes.

Understand the underlying cause of joint pain

Before choosing any supplement, it’s essential to understand why your joints hurt. 

Joint discomfort can stem from various causes, including arthritis, overuse, prior injuries, age-related degeneration, autoimmune conditions, or nutrient deficiencies.

According to the Arthritis Foundation, there are over 100 types of arthritis; hence, a healthcare provider is needed to help identify the cause and confirm whether supplements are appropriate, or if other treatments should come first. 

This step prevents wasted money and ensures you’re selecting the right supplements that match your needs.

Check for medication interactions

Many joint supplements can interact with common prescriptions. For example:

• Fish oil, turmeric, MSM, and vitamin E may interact with blood thinners

• Certain herbal supplements may affect blood pressure medications.

• Anti-inflammatory herbs can sometimes interact with anti-anxiety, antidepressant, or immunosuppressant drugs

Even though supplements are available over-the-counter, always confirm safety with your doctor or pharmacist.

Review allergy information and sensitivities

Always read labels carefully. Some joint health supplements contain ingredients that may be allergens, for example:

• Fish oil supplement (derived from fish)

• Glucosamine (sometimes derived from shellfish)

• Herbal blends (which may contain multiple botanicals)

If you have allergies or dietary restrictions, choose brands that clearly list all ingredients and sourcing details. Reputable companies openly disclose allergens and manufacturing practices.

Consider the supplement form, size, and convenience

Many supplements often require larger serving sizes; it’s essential to choose a format you can comfortably take. 

Consider:

• Pill size (some joint capsules are quite large)

• Number of doses per day (some require 2–6 capsules daily)

• Alternative formats (powders, liquids, or gummies)

If you struggle with large pills, a powdered or liquid option may be easier. 

Compare cost and serving size carefully

Prices for joint supplements vary widely, and a higher cost doesn’t always mean higher quality. When comparing products, consider:

• Cost per dose (not just cost per bottle)

• Serving size and number of capsules

• Whether the supplement contains researched doses or just trace amounts

It’s common for effective joint supplements to cost $25–$40 per month, but prices beyond that are usually due to branding, not superior science.

Assess ingredient quality and additives

Check the fine print. The best supplements avoid:

• Artificial colors

• Artificial flavors

• Unnecessary preservatives

• Excess fillers

• Sugar or sugar alcohols in large amounts

Brands like Why Not Natural prioritize clean formulations and transparency, giving you exactly what you need without unnecessary extras.

Evaluate whether the nutrient is better obtained from food

Not every nutrient needs to come from a supplement. For example:

• Omega-3s can come from salmon, sardines, or mackerel

• Turmeric can be incorporated into meals

Your doctor may recommend a blood test to identify deficiencies before you start supplementing. Sometimes dietary changes or physical therapy may offer more benefits than supplements alone.

Best practices for safe supplement use

If you choose to add supplements to your routine, the following best practices will help you use them safely, effectively, and confidently.

Use supplements as an addition, not a replacement

Joint supplements shouldn’t replace arthritis medications or other treatments your doctor has prescribed. Only FDA-approved medications have been proven to slow joint degeneration or treat underlying conditions. 

Supplements play a supportive role; they may help with comfort, mobility, stiffness, and nutrient gaps, and can help you take less pain medication, but they are not cures or primary therapies.

Consult your doctor before starting anything new

Before taking any new supplement, especially one aimed at joint health, check with your healthcare provider. This is important for a few reasons:

• They understand the cause of your joint pain, which determines which supplements (if any) are appropriate.

• They can confirm safe dosages, especially for ingredients like MSM, turmeric, vitamin E, or glucosamine.

• They can evaluate interactions with existing medications, including common prescriptions such as blood thinners, antidepressants, or blood pressure drugs.

• They can help identify nutrient deficiencies, like vitamin D deficiency, which may require targeted supplementation.

Start with one supplement at a time

When beginning a new routine, start slowly. Adding too many supplements at once makes it hard to know what’s working or what’s causing side effects.

Follow the recommended dosage (and don’t assume more is better)

Research-backed dosages exist for many joint ingredients, including MSM, turmeric, glucosamine, chondroitin, vitamin D, and more. Taking more than recommended doesn’t improve results and may increase the risk of side effects.

If you’re unsure whether you’re taking the right amount, ask your doctor or pharmacist for guidance.

Monitor how your body responds

Track changes in:

• Pain

• Stiffness

• Mobility

• Swelling

• Muscle recovery

• Daily comfort

If you see improvement after several weeks, it’s a sign the supplement is helping. If you notice no improvement—or new symptoms—talk to your doctor. Some supplements need time to show benefits, while others may simply not be the right fit for your body.

Store supplements properly

Keep supplements in a cool, dry place away from sunlight. Heat and humidity can break down active ingredients, making them less effective. Always seal the bottle tightly and check expiration dates.

If you have young family members or pets in the home, store supplements safely out of reach.

Reevaluate your routine regularly

Your joint health needs can change over time. What worked last year might not be necessary today, and vice versa. At least once or twice a year, review your supplement routine with a healthcare provider.

Tips for maximizing results 

While quality and dosage matter, how you take your supplements often determines how well your body can use them. These simple, research-backed tips will help you get the greatest benefit from any joint-health routine.

Take supplements consistently

Consistency is one of the biggest predictors of success. Many joint supplements, such as glucosamine, chondroitin, MSM, and turmeric, work gradually. Your body needs steady levels of these ingredients to maintain their effects.

Helpful habits include:

• Taking supplements at the same time each day

• Using a pill organizer or setting reminders

• Keeping supplements somewhere visible (but away from heat or moisture)

The more consistent you are, the better your long-term results tend to be.

Pair supplements with the right meals

Some supplements absorb best when taken with food—particularly those that are fat-soluble or may cause mild stomach discomfort on an empty stomach.

General guidelines include:

• Take fat-soluble vitamins (A, D, E, K) with a meal that includes healthy fats

• Take turmeric or curcumin with food to improve tolerance and enhance absorption

• Take glucosamine or MSM with breakfast or lunch to reduce GI discomfort

• Check the label for timing instructions, as certain minerals can interfere with each other

Pair supplements with healthy lifestyle habits

Even the best joint supplement cannot replace the basics of joint health. For long-term comfort and mobility, combine supplements with:

• Low-impact exercise, such as walking, swimming, cycling, or yoga, to keep your joints functioning well

• Strength training to support muscles around the joints

• Anti-inflammatory nutrition, including omega-3-rich foods, antioxidants, and whole grains

• Stress management, since stress can heighten pain perception

• Healthy sleep, which supports recovery and reduces inflammation

Stay hydrated

Water plays a key role in nutrient transport and joint lubrication. Proper hydration also supports cartilage health. 

Drinking enough water each day may help enhance how effectively your body uses supplements, especially those meant to support connective tissues.

Aim for regular hydration throughout the day, not just at meals.

Support supplements with a joint-healthy diet

Supplements work best when your foundational nutrition is strong. A diet that supports joint comfort includes:

• Colorful fruits and vegetables for antioxidants

• Omega-3–rich foods like salmon, walnuts, and chia seeds

• Lean proteins and collagen-rich foods (bone broth, eggs)

• Anti-inflammatory spices like turmeric and ginger

• Whole grains, beans, and legumes

Avoid interactions that reduce absorption

Certain nutrients can interfere with each other or with medications. To get the most out of your supplements:

• Skip taking supplements with high-caffeine drinks, which may hinder absorption

• Avoid combining supplements that duplicate the same ingredient unless approved by your doctor

• Double-check that none of your supplements conflict with prescriptions

If you’re taking multiple products, ask your doctor or pharmacist to review your stack.

Takeaway: Your joints deserve a full-circle approach

Keeping your joints healthy takes more than a single pill. It calls for a thoughtful, whole-body approach that blends the right supplements with smart lifestyle choices. 

Understanding why your joints hurt and what contributes to wear and tear helps you make informed decisions about the nutrients your body needs most.

Throughout this guide, we covered supplements like glucosamine and chondroitin, MSM, collagen, omega-3s, and several anti-inflammatory herbs. Each offers unique benefits, but the right choice depends on your individual needs, goals, and any underlying health conditions. 

A personalized plan—built with the help of a doctor—ensures you’re addressing both symptoms and root causes.

If you're ready to take the next step toward better joint comfort and mobility, consider exploring Why Not Natural’s clean joint formulas, carefully crafted to support your active, healthy lifestyle.

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